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BioPro IEX Series

BioPro IEX Q/S and BioPro IEX SmartSep Q/S, ion exchange media with high dynamic binding capacities and high recoveries, are suitable for downstream chromatographic purification processes in biopharmaceutical manufacturing. BioPro IEX Q/S and BioPro IEX SmartSep Q/S are suitable for initial purification (capture) and for intermediate to final purification (polishing), respectively.
BioPro IEX Column, ion exchange columns with high resolution, are suitable for uniformity tests, such as isoform analysis in quality control and characterization of biopharmaceuticals.

Media

  BioPro IEX Q/S BioPro IEX SmartSep Q/S
BioPro IEX Q BioPro IEX S BioPro IEX SmartSep Q BioPro IEX SmartSep S
Matrix Hydrophilic porous polymer
Particle size (μm) 75 10, 20, 30
Charged group -R-N+(CH3)3 -R-SO3- -R-N+(CH3)3 -R-SO3-
Feature Suitable for capture and intermediate purification step
High binding capacity		 Suitable for intermediate purification step and polishing step
High-throughput purification by utilizing mechanical strength
polymer beads

BioPro Ion Exchange Screening Kit

        Available in strong ion exchangers (Q and S chemistries)
        For media screening, develop of purification method and loadability study

Column

  BioPro IEX Column
BioPro IEX QF BioPro IEX SF BioPro IEX QA BioPro IEX SP
Matrix Hydrophilic non-porous polymer Hydrophilic porous polymer
Particle size (μm) 3, 5 5
Charged group -CH2N+(CH3)3 -CH2CH2CH2SO3- -CH2N+(CH3)3 -CH2CH2CH2SO3-
Feature For increasing resolution and throughput
High efficiency with low operating pressure
Suitable for characterization of biopharmaceuticals and quality control 		Suitable for laboratory-scale purification
High binding capacity and high recovery of biomolecules

Products subjected to purification process of biopharmaceuticals

Process Required media performance Products
Capture
  • High binding capacity in high flow rate
  • Excellent characteristic of pressure and flow rate realizing high flow rate
 BioPro IEX Q/S
(75 μm)
Intermediate
  • High resolution to remove most of impurity
  • High binding capacity
  • Easy to scale up
  • Excellent mechanical strength and pressure resistance
 BioPro IEX SmartSep Q/S
(10, 20, 30 μm)
Polishing
  • Quite high performance to separate impurities whose retention time close to each other
  • Low nonspecific binding capacity
Analytical
  • High resolution and excellent lot-to-lot reproducibility
 BioPro IEX Column
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